ABSTRACT
Background: Diabetes mellitus is the most common metabolic disorder complicating pregnancy. The incidence of pre-gestational (type 1 and type 2) and gestational diabetes mellitus is on the rise in India. Authors aimed to study the clinical profile and outcome of the infant of diabetic mothers.Methods: The study was conducted in the Sick Newborn Care Unit attached to Stanley Medical College in Chennai over a period of 6 months. All infants born to diabetic mothers during the study period were included in the study.Results: Among the total of 6236 babies delivered in total during the study period, 566 (9.07%) were born to diabetic mothers. 16.25% were pre-gestational diabetic mothers and 83.75% were GDM Mothers. The incidence of prematurity was 15.2% and LGA was 7.9%. The majority were AGA (495 out of 566). Symptomatic Hypoglycemia was observed in 16 babies and asymptomatic hypoglycemia in 35 babies with total occurrence of hypoglycemia in 9% of babies. Hyper-bilirubinemia is the most common problem encountered in 29% of babies, congenital heart disease and renal problems were the most common congenital anomalies noted in IDM 44 out of 566 babies (7.8%).Conclusions: There is lack of awareness regarding dog bite and its management among the rural populatEarly detection and optimal management of diabetic status during the antenatal period along with anticipation, early recognition and management of postnatal complications will reduce the mortality of infants of diabetic mothersion.
ABSTRACT
PURPOSE: Jaundice accounts for most hospital admissions in the neonatal period. Nowadays, in addition to phototherapy, other auxiliary methods are used to reduce jaundice and the length of hospitalization. This study aimed to investigate the effect of probiotics on the treatment of hyper-bilirubinemia in full-term neonates. METHODS: In this randomized clinical trial, 83 full-term neonates, who were admitted to the hospital to receive phototherapy in the first 6 months of 2015, were randomly divided into two groups: synbiotic (SG, n=40) and control (CG, n=43). Both groups received phototherapy but the SG also received 5 drops/day of synbiotics. Serum bilirubin, urine, stool, feeding frequency, and weight were measured daily until hospital discharge. A p-value<0.05 was considered statistically significant. RESULTS: The mean total serum bilirubin in the SG was lower than that in the CG (9.38±2.37 and 11.17±2.60 mg/dL, respectively). The urine and stool frequency in the SG was significantly higher than that in the CG (p<0.05). The duration of hospitalization in the SG was shorter than that in the CG. CONCLUSION: Use of synbiotics as an adjuvant therapy had a significant treatment effect on jaundice in full-term neonates. Further studies including larger samples with long follow-up periods are essential to confirm the benefits of routine use of synbiotics in neonatal patients with jaundice.
Subject(s)
Humans , Infant, Newborn , Bilirubin , Follow-Up Studies , Hospitalization , Jaundice , Phototherapy , Probiotics , SynbioticsABSTRACT
Gestational diabetes mellitus(GDM) has serious ramifications on the offspring such as Hypoxemia, Visceromegaly, Perinatal mortality, Hyper bilirubinemia, Obesity, Hyperglycemia, reduced immune function and cognitive function. Gestational diabetes is known to effect placental metabolism, growth, and development. The maternal and fetal hyperglycaemia have an impact on the production of placental proteins. Concerns regarding these denouements are escalating rapidly in the developing countries, there is a need of deeper understanding pertaining to the pathophysiological, therapeutic and preventive measures of GDM. Lack of awareness among the patients is also responsible for fetal abnormalities caused by GDM. In this review we have given a brief account of Fetal Developmental Trajectory, Intrauterine exposure to gestational diabetes, Placental impairment and Modifications in materno-placental oxygen supply. At the end, we have noted the impact of Embryonic Amino Acid Metabolism during Early Pregnancy.
ABSTRACT
0.05). Compared with the healthy neonates, the concentration of blood MDA and ROS was significantly higher, and that of blood HB and SOD was significantly lower in both groups(P